4-hydroxyestrone-4-methyl ether
| Code | Size | Price |
|---|
| TAR-T9455-1mg | 1mg | £328.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
4-hydroxyestrone-4-methyl ether is the methylation of 4-OHE1, which is catalyzed by COMT.
CAS:
58562-33-7
Formula:
C38H47O6
Molecular Weight:
599.78
Pathway:
Metabolism; Endocrinology/Hormones
Purity:
0.98
SMILES:
C[C@](CC1)([C@@H](CC2)[C@H](CC3)[C@H]1c(cc1)c3c(OC)c1O)C2=OC[C@](CC1)([C@@H](CC2)[C@H](CC3)[C@H]1c(cc1)c3c(OC)c1O)C2=O
Target:
Estrogen Receptor/ERR; Endogenous Metabolite
References
Lippert C, et al. The effects of A-ring and D-ring metabolites of estradiol on the proliferation of vascular endothelial cells. Life Sci. 2000 Aug 18;67(13):1653-8.
Emons G, et al. Radioimmunoassay for 4-hydroxyestrone 4-methyl ether in human urine. Horm Metab Res. 1982 Jul;14(7):376-9.
Dawling S, et al. Catechol-O-methyltransferase (COMT)-mediated metabolism of catechol estrogens: comparison of wild-type and variant COMT isoforms. Cancer Res. 2001 Sep 15;61(18):6716-22.