3'-Demethylnobiletin
Code | Size | Price |
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TAR-TN1244-1mg | 1mg | £138.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-TN1244-5mg | 5mg | £228.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-TN1244-1mL | 1 mL * 10 mM (in DMSO) | £247.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-TN1244-10mg | 10mg | £307.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Images
Documents
Further Information
Bioactivity:
3'-Demethylnobiletin has chemopreventive effects on colon carcinogenesis, it can significantly inhibit the growth of human colon cancer cells, cause cell-cycle arrest, induce apoptosis, and profoundly modulate signaling proteins related with cell proliferation and cell death.
CAS:
112448-39-2
Formula:
C20H20O8
Molecular Weight:
388.372
Pathway:
Metabolism; Cytoskeletal Signaling; DNA Damage/DNA Repair; Cell Cycle/Checkpoint; NF-κb
Purity:
0.9987
SMILES:
COc1ccc(cc1O)-c1cc(=O)c2c(OC)c(OC)c(OC)c(OC)c2o1
Target:
LDL; NF-κB; Integrin; Lipoxygenase; DNA/RNA Synthesis
References
Eguchi A, et al. Suppressive effects of demethylated metabolites of nobiletin on phorbol ester-induced expression of scavenger receptor genes in THP-1 human monocytic cells. Biofactors. 2007;31(2):107-16.