Swainsonine
| Code | Size | Price |
|---|
| TAR-TN2344-1mg | 1mg | £270.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-TN2344-1mL | 1 mL * 10 mM (in DMSO) | £452.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
Swainsonine is an alkaloid isolated from Astragalus, acts as an inhibitor of α-mannosidase, with anti-tumor activity.
CAS:
72741-87-8
Formula:
C8H15NO3
Molecular Weight:
173.212
Pathway:
Microbiology/Virology|Others|Apoptosis
Purity:
0.98
SMILES:
O[C@@H]1CN2CCC[C@@H](O)[C@@H]2[C@@H]1O
Target:
Apoptosis|Others|Antibiotic
References
Santos FM, et al. Increased antitumor efficacy by the combined administration of swainsonine and cisplatin in vivo. Phytomedicine. 2011 ; 18(12):1096-1101.
Silveira CRF, et al. Swainsonine, an alpha-mannosidase inhibitor, may worsen cervical cancer progression through the increase in myeloid derived suppressor cells population. PLoS One. 2019 ; 14(3):e0213184.
Tulsiani DR, et al. Marked differences in the swainsonine inhibition of rat liver lysosomal alpha-D-mannosidase, rat liver Golgi mannosidase II, and jack bean alpha-D-mannosidase. Arch Biochem Biophys. 1985 ; 236(1):427-434.
Reddy BV, et al. Sialilated beta1,6 branched N-oligosaccharides modulate adhesion, chemotaxis and motility of melanoma cells: Effect on invasion and spontaneous metastasis properties. Biochim Biophys Acta. 2006 ; 1760(9):1393-1402.
Sun L, et al. Swainsonine represses glioma cell proliferation, migration and invasion by reduction of miR-92a expression. BMC Cancer. 2019 ; 19(1):247.
Dorling PR, et al. Inhibition of lysosomal alpha-mannosidase by swainsonine, an indolizidine alkaloid isolated from Swainsona canescens. Biochem J. 1980 ; 191(2):649-651.