Agrimonolide
| Code | Size | Price |
|---|
| TAR-TN3364-5mg | 5mg | £1,661.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-TN3364-1mL | 1 mL * 10 mM (in DMSO) | £1,997.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
Agrimonolide is a potential α1 adrenergic receptor antagonist, it exerts anti-inflammatory activity, at least in part, via suppressing LPS-induced activation of JAK-STATs and p38 MAPKs signaling pathway. Agrimonolide and desmethylagrimonolide can effectively increase insulin-mediated glycogen level in heptocytes, they may play an important role in regulating glucose metabolism in insulin-resistance HepG2 cells and could be developed as a promising natural material for diabetes prevention and treatment.
CAS:
21499-24-1
Formula:
C18H18O5
Molecular Weight:
314.3
Pathway:
Chromatin/Epigenetic; GPCR/G Protein; NF-κb; Stem Cells; Immunology/Inflammation; JAK/STAT signaling; Neuroscience; Angiogenesis; Apoptosis; MAPK
Purity:
0.98
SMILES:
COc1ccc(CC[C@H]2Cc3cc(O)cc(O)c3C(=O)O2)cc1
Target:
IL Receptor; p38 MAPK; TNF; NOS; NF-κB; COX; JAK; Adrenergic Receptor; JNK; STAT
References
Liu Y, et al. Agrimonolide inhibits cancer progression and induces ferroptosis and apoptosis by targeting SCD1 in ovarian cancer cells. Phytomedicine. 2022;101:154102.
Chen L, et al. Agrimonolide from Agrimonia pilosa suppresses inflammatory responses through down-regulation of COX-2/iNOS and inactivation of NF-?B in lipopolysaccharide-stimulated macrophages. Phytomedicine. 2016;23(8):846-855.
Teng H, et al. The potential beneficial effects of phenolic compounds isolated from A. pilosa Ledeb on insulin-resistant hepatic HepG2 cells. Food Funct. 2016;7(10):4400-4409.
Wang C, et al. Protective effects of agrimonolide on hypoxia-induced H9c2 cell injury by maintaining mitochondrial homeostasis. J Cell Biochem. 2022;123(2):306-321.