Cedrelone
| Code | Size | Price |
|---|
| TAR-TN3616-1mL | 1 mL * 10 mM (in DMSO) | Enquire | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-TN3616-1mg | 1mg | £631.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
Cedrelone exhibits antifeedant activity, it has insecticidal activity, it inhibits arval growth of P. saucia, and the molting of the milkweed bug, Oncopeltus fasciatus. Cedrelone and its derivatives exert antimicrobial activities, bromohydroxy cedrelone and Michael adduct show good antifungal activity. Cedrelone is also a very potent inducer of apoptosis, it can cause cell cycle arrest, it shows significant cytotoxicity against cancer cell lines, such as -60, SMMC-7721, A-549, MCF-7 and SW480.
CAS:
1254-85-9
Formula:
C26H30O5
Molecular Weight:
422.5
Pathway:
Proteases/Proteasome; Microbiology/Virology
Purity:
0.98
SMILES:
C[C@@]12CC[C@@H]3[C@@]4(C)C=CC(=O)C(C)(C)C4=C(O)C(=O)[C@@]3(C)[C@]11O[C@H]1C[C@H]2c1ccoc1
Target:
MMP; Antifection
References
Fuzer AM, et al. Effects of limonoid cedrelone on MDA-MB-231 breast tumor cells in vitro. Anticancer Agents Med Chem. 2013;13(10):1645-1653.
Wu J, Niu Q, Yuan J, et al. Novel compound cedrelone inhibits hepatocellular carcinoma progression via PBLD and Ras/Rap1. Experimental and Therapeutic Medicine.. 18.6 (2019): 4209-4220
Gopalakrishnan G, et al. Photooxidation of cedrelone, a tetranortriterpenoid from Toona ciliata. Photochem Photobiol. 2000;72(4):464-466.
Wu J, et al. Novel compound cedrelone inhibits hepatocellular carcinoma progression via PBLD and Ras/Rap1. Exp Ther Med. 2019;18(6):4209-4220.
Cao Y, et al. Antitumor activity of Cedrelone in temozolomide-resistant human glioma cells is accompanied by mitochondrial mediated apoptosis, inhibition of angiogenesis, cell cycle disruption and modulation of ERK/MAPK signalling pathway. J BUON. 2019;24(3):1204-1209.