HLM006474

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TargetMol
Product Code: TAR-T15486
Supplier: TargetMol
CodeSizePrice
TAR-T15486-2mg2mg£101.00
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TAR-T15486-5mg5mg£119.00
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TAR-T15486-1mL1 mL * 10 mM (in DMSO)£125.00
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Quantity:
TAR-T15486-10mg10mg£141.00
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TAR-T15486-25mg25mg£204.00
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Quantity:
TAR-T15486-50mg50mg£308.00
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Quantity:
TAR-T15486-100mg100mg£464.00
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TAR-T15486-500mg500mg£946.00
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Quantity:
Prices exclude any Taxes / VAT

Overview

Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃

Images

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Documents

Further Information

Bioactivity:
HLM006474 is a pan inhibitor of E2F. This inhibits E2F4 DNA-binding (IC50: 29.8 μM in A375 cells).
CAS:
353519-63-8
Formula:
C25H25N3O2
Molecular Weight:
399.494
Purity:
0.9904
SMILES:
CCOc1ccc(cc1C)C(Nc1ccccn1)c1ccc2ccc(C)nc2c1O

References

1. Ma Y, et al. A small-molecule E2F inhibitor blocks growth in a melanoma culture model. Cancer Res. 2008 Aug 1;68(15):6292-9. 2. Kurtyka CA, et al. E2F inhibition synergizes with paclitaxel in lung cancer cell lines. PLoS One. 2014 May 15;9(5):e96357.