PF-6274484

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TargetMol
Product Code: TAR-T22396
Supplier: TargetMol
CodeSizePrice
TAR-T22396-2mg2mg£98.00
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TAR-T22396-5mg5mg£115.00
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TAR-T22396-1mL1 mL * 10 mM (in DMSO)£119.00
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Quantity:
TAR-T22396-10mg10mg£145.00
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Quantity:
TAR-T22396-25mg25mg£229.00
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Quantity:
TAR-T22396-50mg50mg£367.00
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Quantity:
TAR-T22396-100mg100mg£511.00
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Quantity:
TAR-T22396-500mg500mg£1,026.00
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Quantity:
Prices exclude any Taxes / VAT

Overview

Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃

Images

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Documents

Further Information

Bioactivity:
PF 6274484, a high affinity, irreversible covalent inhibitor of EGFR kinase with Ki of 0.14 nM, inhibits the autophosphorylation of wild-type EGFR in A549 cells and EGFRL858R/T790M in H1975 cells with IC50 of 5.8 nM and 6.6 nM, respectively.
CAS:
1035638-91-5
Formula:
C18H14ClFN4O2
Molecular Weight:
372.78
Pathway:
Tyrosine Kinase/Adaptors; JAK/STAT signaling; Angiogenesis
Purity:
0.9912
SMILES:
COc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1NC(=O)C=C
Target:
EGFR