CL-387785

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TargetMol
Product Code: TAR-T2245
Supplier: TargetMol
CodeSizePrice
TAR-T2245-1mg1mg£97.00
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TAR-T2245-2mg2mg£107.00
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TAR-T2245-5mg5mg£115.00
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TAR-T2245-1mL1 mL * 10 mM (in DMSO)£119.00
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TAR-T2245-10mg10mg£142.00
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TAR-T2245-25mg25mg£213.00
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TAR-T2245-50mg50mg£301.00
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TAR-T2245-100mg100mg£442.00
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TAR-T2245-500mg500mg£863.00
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Prices exclude any Taxes / VAT

Overview

Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃

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Documents

Further Information

Bioactivity:
CL-387785(EKI785; WAY-EKI 785) is an irreversible inhibitor of EGFR?IC50? 370+/-120 pM?; is able to overcome resistance caused by the T790M mutation on a functional level.
CAS:
194423-06-8
Formula:
C18H13BrN4O
Molecular Weight:
381.233
Pathway:
Angiogenesis; Tyrosine Kinase/Adaptors; JAK/STAT signaling
Purity:
0.9668
SMILES:
CC#CC(=O)Nc1ccc2ncnc(Nc3cccc(Br)c3)c2c1
Target:
EGFR

References

1. Discafani CM, et al. Biochem Pharmacol. 1999, 57(8), 917-925. 2. William E, et al. Kidney International. 2000, 57(1), 33-40. 3. Hama T, et al. Clin Exp Metastasis. 2012, 29(1), 19-25. 4. Kancha RK, et al. PloS ONE. 2011, 6(10), e26760. 5. Roberts RB, et al. Proc Natl Acad Sci. 2002, 99(3), 1521-1526.