MRT-10

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TargetMol
Product Code: TAR-T23027
Supplier: TargetMol
CodeSizePrice
TAR-T23027-1mg1mg£124.00
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TAR-T23027-2mg2mg£147.00
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TAR-T23027-1mL1 mL * 10 mM (in DMSO)£189.00
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TAR-T23027-5mg5mg£189.00
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TAR-T23027-10mg10mg£254.00
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TAR-T23027-25mg25mg£462.00
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TAR-T23027-50mg50mg£646.00
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TAR-T23027-100mg100mg£863.00
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TAR-T23027-500mg500mg£1,661.00
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Prices exclude any Taxes / VAT

Overview

Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃

Images

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Documents

Further Information

Bioactivity:
MRT 10 is a smoothened (Smo) receptor antagonist (an IC50 = 0.5 μM in HEK293 cells transiently expressing mouse Smo). It also inhibits bodipy-cyclopamine binding to the murine Smo receptor (an IC50 = 0.5 μM
CAS:
330829-30-6
Formula:
C24H23N3O5S
Molecular Weight:
465.52
Pathway:
GPCR/G Protein; Stem Cells
Purity:
0.9947
SMILES:
COc1cc(cc(OC)c1OC)C(=O)NC(=S)Nc1cccc(NC(=O)c2ccccc2)c1
Target:
Hedgehog/Smoothened

References

1. Solinas et al (2012) Acylthiourea, acylurea, and acylguanidine derivatives with potent hedgehog inhibiting activity. J.Med.Chem. 55 1559