Ro 67-7476

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TargetMol
Product Code: TAR-T3478
Supplier: TargetMol
CodeSizePrice
TAR-T3478-1mg1mg£95.00
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TAR-T3478-2mg2mg£105.00
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TAR-T3478-1mL1 mL * 10 mM (in DMSO)£131.00
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TAR-T3478-5mg5mg£139.00
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TAR-T3478-10mg10mg£177.00
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TAR-T3478-25mg25mg£288.00
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TAR-T3478-50mg50mg£464.00
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TAR-T3478-100mg100mg£645.00
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Prices exclude any Taxes / VAT

Overview

Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃

Images

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Documents

Further Information

Bioactivity:
Ro 67-7476 is a positive allosteric modulator of mGlu1 receptors. No activity at human mGlu1 receptors. Potentiates glutamate-induced calcium release with EC 50 of 60.1 nM.
CAS:
298690-60-5
Formula:
C17H18FNO2S
Molecular Weight:
319.39
Pathway:
Neuroscience
Purity:
0.9948
SMILES:
Cc1ccc(cc1)S(=O)(=O)N1CCC[C@H]1c1ccc(F)cc1
Target:
GluR

References

Knoflach F et al. Positive allosteric modulators of metabotropic glutamate 1 receptor: characterization, mechanism of action, and binding site. Proc Hemstapat K et al. A novel class of positive allosteric modulators of metabotropic glutamate receptor subtype 1 interact with a site distinct from that of negative allosteric modulators. Mol Pharmacol. 2006 Aug, 70(2), 616-26