GSK269962A

Contact us
TargetMol
Product Code: TAR-T3518
Supplier: TargetMol
CodeSizePrice
TAR-T3518-1mg1mg£99.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
TAR-T3518-2mg2mg£112.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
TAR-T3518-5mg5mg£136.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
TAR-T3518-1mL1 mL * 10 mM (in DMSO)£157.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
TAR-T3518-10mg10mg£193.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
TAR-T3518-25mg25mg£330.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
TAR-T3518-50mg50mg£455.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
TAR-T3518-100mg100mg£623.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
Prices exclude any Taxes / VAT

Overview

Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃

Images

1 / 1
❮❯

Documents

Further Information

Bioactivity:
GSK269962 is a selective ROCK(Rho-associated protein kinase) inhibitor with IC50 values of 1.6 and 4 nM for ROCK1 and ROCK2, respectively.
CAS:
850664-21-0
Formula:
C29H30N8O5
Molecular Weight:
570.61
Pathway:
Cytoskeletal Signaling; MAPK; PI3K/Akt/mTOR signaling; Cell Cycle/Checkpoint; Stem Cells
Purity:
0.9959
SMILES:
CCn1c(nc2cnc(Oc3cccc(NC(=O)c4ccc(OCCN5CCOCC5)cc4)c3)cc12)-c1nonc1N
Target:
ROCK; S6 Kinase

References

Mondal T, Shivange G N, Tihagam R G T, et al. Unexpected PD?L1 immune evasion mechanism in TNBC, ovarian, and other solid tumors by DR5 agonist antibodies. EMBO Molecular Medicine. 2021 Mar 5;13(3):e12716. doi: 10.15252/emmm.202012716. Epub 2021 Feb 15. Mondal T, Shivange G N, Tihagam R G T, et al. Unexpected PD?L1 immune evasion mechanism in TNBC, ovarian, and other solid tumors by DR5 agonist antibodies. EMBO Molecular Medicine. 2021: e12716. Xu Q, Fu Q, Li Z, et al. Procyanidin C1 is a natural agent with senolytic activity against aging and age-related diseases. EMBO Molecular Medicine. (2021)13:e12716 Xu Q, Fu Q, Li Z, et al. Procyanidin C1 is a natural agent with senolytic activity against aging and age-related diseases[J]. bioRxiv. 2021 Doe C, et al. J Pharmacol Exp Ther. 2007, 320(1):89-98. Andrzej Wr?bel, et al. Neurourology and Urodynamics. 2016.