K-Ras(G12C) Inhibitor 6

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TargetMol
Product Code: TAR-T3725
Supplier: TargetMol
CodeSizePrice
TAR-T3725-1mg1mg£116.00
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TAR-T3725-2mg2mg£136.00
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TAR-T3725-1mL1 mL * 10 mM (in DMSO)£179.00
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TAR-T3725-5mg5mg£179.00
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TAR-T3725-10mg10mg£266.00
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TAR-T3725-25mg25mg£475.00
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TAR-T3725-50mg50mg£634.00
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TAR-T3725-100mg100mg£858.00
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Prices exclude any Taxes / VAT

Overview

Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃

Images

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Documents

Further Information

Bioactivity:
K-Ras(G12C) inhibitor 6 is an irreversible, allosteric inhibitor of the K-Ras(G12C) mutant that causes 100% modification of the protein when used at 10 μM for 24 hours in vitro.
CAS:
2060530-16-5
Formula:
C17H22Cl2N2O3S
Molecular Weight:
405.33
Pathway:
MAPK
Purity:
0.98
SMILES:
SCCCC(=O)NC1CCN(CC1)C(=O)COc1ccc(Cl)cc1Cl
Target:
Raf

References

Hunter JC, Gurbani D, Ficarro SB, Carrasco MA, Lim SM, Choi HG, Xie T, Marto JA, Chen Z, Gray NS, Westover KD. Proc Natl Acad Sci U S A. 2014 Jun 17;111(24):8895-900. Lim SM, Westover KD, Ficarro SB, Harrison RA, et al.Angew Chem Int Ed Engl. 2014 Jan 3;53(1):199-204. Sakamoto K, Kamada Y, Sameshima T,et al. Biochem Biophys Res Commun. 2017 Mar 11;484(3):605-611.