LP-922056

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TargetMol
Product Code: TAR-T38776
Supplier: TargetMol
CodeSizePrice
TAR-T38776-1mg1mg£95.00
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TAR-T38776-2mg2mg£106.00
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TAR-T38776-5mg5mg£127.00
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TAR-T38776-1mL1 mL * 10 mM (in DMSO)£132.00
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TAR-T38776-10mg10mg£164.00
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TAR-T38776-25mg25mg£252.00
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TAR-T38776-50mg50mg£362.00
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TAR-T38776-100mg100mg£547.00
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Quantity:
Prices exclude any Taxes / VAT

Overview

Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃

Images

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Documents

Further Information

Bioactivity:
LP-922056 is an inhibitor of Notum Pectinacetylesterase with EC50 values of 21 nM, 55 nM for human and mouse, respectively.
CAS:
1365060-22-5
Formula:
C11H9ClN2O2S2
Molecular Weight:
300.78
Pathway:
Cytoskeletal Signaling; Stem Cells
Purity:
0.98
SMILES:
O=C(O)CSC1=NC=NC2=C1SC(Cl)=C2C3CC3
Target:
Wnt/beta-catenin

References

James E Tarver Jr, et al. Stimulation of cortical bone formation with thienopyrimidine based inhibitors of Notum Pectinacetylesterase. Bioorg Med Chem Lett. 2016 Mar 15;26(6):1525-1528. Robert Brommage, et al. NOTUM inhibition increases endocortical bone formation and bone strength. Bone Res. 2019 Jan 8;7:2.