CLOZAPINE N-OXIDE
Code | Size | Price |
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TAR-T4494-2mg | 2mg | £95.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Quantity:
TAR-T4494-5mg | 5mg | £109.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T4494-1mL | 1 mL * 10 mM (in DMSO) | £113.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T4494-10mg | 10mg | £133.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T4494-25mg | 25mg | £172.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T4494-50mg | 50mg | £221.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T4494-100mg | 100mg | £296.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Images
Documents
Further Information
Bioactivity:
Clozapine N-oxide is a major metabolite of clozapine that can be detected in the earliest excretion time interval after clozapine administration [1]. It is produced by the action of cytochrome P450 (CYP) isoforms CYP1A2 and CYP3A4, whose activities, in turn, can be affected by drugs and disease [2]. Clozapine N-oxide is normally biologically inactive. However, it can be used in designer receptor exclusively activated by designer drugs, also known as DREADDs, technology to modulate synthetic receptors in vivo [3].
CAS:
34233-69-7
Formula:
C18H19ClN4O
Molecular Weight:
342.83
Pathway:
GPCR/G Protein; Neuroscience; Metabolism
Purity:
0.9994
SMILES:
C[N+]1([O-])CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2ccccc12
Target:
Dopamine Receptor; 5-HT Receptor; AChR; Drug Metabolite
References
Wang Y, Liu N, Ma L, et al.Ventral Hippocampal CA1 Pyramidal Neurons Encode Nociceptive Information.Neuroscience Bulletin.2023: 1-17.
Eiermann, B., et al. The involvement of CYP1A2 and CYP3A4 in the metabolism of clozapine. British Journal of Clinical Pharmacology 44(5), 439-446 (1997).
Ray, R.S., et al. Impaired respiratory and body temperature control upon acute serotonergic neuron inhibition. Science 333(6042), 637-642 (2012).
Ma X, Li L, Li Z, et al. eEF2 in the prefrontal cortex promotes excitatory synaptic transmission and social novelty behavior. EMBO reports. 2022: e54543.
Dain, J.G., et al. Biotransformation of clozapine in humans. Drug Metabolism and Disposition 25(5), 603-609 (1997).