DC661

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TargetMol
Product Code: TAR-T5538
Supplier: TargetMol
CodeSizePrice
TAR-T5538-1mg1mg£129.00
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TAR-T5538-2mg2mg£156.00
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TAR-T5538-5mg5mg£230.00
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TAR-T5538-1mL1 mL * 10 mM (in DMSO)£265.00
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TAR-T5538-10mg10mg£340.00
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TAR-T5538-25mg25mg£531.00
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TAR-T5538-50mg50mg£731.00
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TAR-T5538-100mg100mg£978.00
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Prices exclude any Taxes / VAT

Overview

Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃

Images

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Documents

Further Information

Bioactivity:
DC661 is palmitoyl-protein thioesterase 1 (PPT1) inhibitor, inhibits autophagy, and acts as an anti-lysosomal agent. Anti-cancer activity
CAS:
1872387-43-3
Formula:
C31H39Cl2N5
Molecular Weight:
552.59
Pathway:
Apoptosis; Autophagy
Purity:
0.98
SMILES:
CN(CCCCCCNc1ccnc2cc(Cl)ccc12)CCCCCCNc1ccnc2cc(Cl)ccc12
Target:
Apoptosis; Autophagy

References

Xu J, Su Z, Cheng X, et al. High PPT1 expression predicts poor clinical outcome and PPT1 inhibitor DC661 enhances sorafenib sensitivity in hepatocellular carcinoma. Cancer Cell International. 2022, 22(1): 1-20. Rebecca VW, et al. PPT1 Promotes Tumor Growth and Is the Molecular Target of Chloroquine Derivatives in Cancer. ancer Discov. 2019 Feb;9(2):220-229.