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TargetMol
Product Code: TAR-T5S1632
Supplier: TargetMol
CodeSizePrice
TAR-T5S1632-1mg1mg£98.00
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TAR-T5S1632-2mg2mg£109.00
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TAR-T5S1632-5mg5mg£132.00
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TAR-T5S1632-1mL1 mL * 10 mM (in DMSO)£138.00
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TAR-T5S1632-10mg10mg£164.00
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TAR-T5S1632-25mg25mg£277.00
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TAR-T5S1632-50mg50mg£370.00
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TAR-T5S1632-100mg100mg£522.00
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Overview

Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃

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Documents

Further Information

Bioactivity:
8-O-Acetylshanzhiside methylester has potential against cerebral ischemic injury, and its protective effect on oxygen-glucose deprivation-induced injury might be due to the suppression of intracellular Ca2+ elevation and caspase-3 activity, and improvement of mitochondrial energy metabolism.8-O-Acetylshanzhiside methylester can increase angiogenesis and improve functional recovery after stroke.8-O-Acetylshanzhiside methylester has protective effects on experimental myocardial ischemia injury, the effects might be due to block of myocardial inflammatory cascades through an HMGB1-dependent NF-κB signaling pathway.8-O-Acetylshanzhiside methylester protects diabetic brain against I/R injury by alleviating diabetic cerebral I/R injury and attenuating blood?brain barrier (BBB) breakdown, and its protective effects may involve HMGB-1 and NF-κB signalling pathway.
CAS:
57420-46-9
Formula:
C19H28O12
Molecular Weight:
448.421
Pathway:
Proteases/Proteasome; Angiogenesis; Apoptosis; PI3K/Akt/mTOR signaling; Tyrosine Kinase/Adaptors; NF-κb; Cytoskeletal Signaling
Purity:
0.9983
SMILES:
COC(=O)C1=CO[C@@H](O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)[C@H]2[C@@H]1[C@H](O)C[C@]2(C)OC(C)=O
Target:
VEGFR; TNF; NF-κB; Akt; Caspase

References

Zhang L, et al.8-O-acetyl shanzhiside methylester attenuates cerebral ischaemia/reperfusion injury through an anti-inflammatory mechanism in diabetic rats.Send to Basic Clin Pharmacol Toxicol. 2014 Dec;115(6):481-7. Jiang WL, et al.Effect of 8-O-acetyl shanzhiside methylester increases angiogenesis and improves functional recovery after stroke.Basic Clin Pharmacol Toxicol. 2011 Jan;108(1):21-7. Kang ZC, Jiang WL, et al.Cardioprotection with 8-O-acetyl shanzhiside methylester on experimental myocardial ischemia injury.Send to