Vadimezan
Code | Size | Price |
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TAR-T6273-2mg | 2mg | £109.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T6273-5mg | 5mg | £136.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T6273-1mL | 1 mL * 10 mM (in DMSO) | £143.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T6273-10mg | 10mg | £159.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T6273-25mg | 25mg | £262.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T6273-50mg | 50mg | £417.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T6273-100mg | 100mg | £452.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Images
Documents
Further Information
Bioactivity:
Vadimezan is a fused tricyclic analogue of flavone acetic acid with potential antineoplastic activity. Vadimezan induces the cytokines tumor necrosis alpha (TNF-alpha), serotonin and nitric oxide, resulting in hemorrhagic necrosis and a decrease in angiogenesis. This agent also stimulates the anti-tumor activity of tumor-associated macrophages.
CAS:
117570-53-3
Formula:
C17H14O4
Molecular Weight:
282.295
Pathway:
Immunology/Inflammation; Microbiology/Virology; Angiogenesis
Purity:
0.998
SMILES:
Cc1ccc2c(oc3c(CC(O)=O)cccc3c2=O)c1C
Target:
Influenza Virus; VDA; STING; IFNAR
References
Liu JJ, et al. Cancer Chemother Pharmacol. 2007, 59(5), 661-669.
Zhao M, Wang B, Zhang C, et al. The DJ1-Nrf2-STING axis mediates the neuroprotective effects of Withaferin A in Parkinson?s disease[J]. Cell Death & Differentiation. 2021: 1-19.
Buchanan CM, et al. Clin Sci (Lond). 2012, 122(10), 449-457.
Shirey KA, et al. J Leukoc Biol. 2011, 89(3), 351-357.
Chen C, Zhang Y, Tao M, et al. Atrial Natriuretic Peptide Attenuates Colitis via Inhibition of the cGAS-STING Pathway in Colonic Epithelial Cells. International Journal of Biological Sciences. 2022, 18(4): 1737-1754.
Chen C, Yan W, Zhang Y, et al. ANP Attenuates Intestinal Inflammation by Regulating STING Pathway[J]. Available at SSRN 3756807.
Phillips RM. Biochem Pharmacol. 1999, 58(2), 303-310.
Zhao M, Wang B, Zhang C, et al. The DJ1-Nrf2-STING axis mediates the neuroprotective effects of Withaferin A in Parkinson?s disease. Cell Death & Differentiation. 2021: 1-19.