KU-57788

Feng Y L, Liu S C, Chen R D, et al.Proximal binding of dCas9 at a DNA double strand break stimulates homology-directed repair as a local inhibitor of classical non-homologous end joining.Nucleic Acids Research.2023: gkad116. Robert F, et al. Pharmacological inhibition of DNA-PK stimulates Cas9-mediated genome editing. Genome Med. 2015 Aug 27;7:93. Zhang B, Wu H, Hao J, et al. Inhibition of DNA-PKcs activity re-sensitizes uveal melanoma cells to radio-and chemotherapy[J]. Biochemical and Biophysical Research Communications. 2019 Sunada S, et al. Nontoxic concentration of DNA-PK inhibitor NU7441 radio-sensitizes lung tumor cells with little effect on double strand break repair. Cancer Sci. 2016 Sep;107(9):1250-5. Zhao Y, et al. Preclinical evaluation of a potent novel DNA-dependent protein kinase inhibitor NU7441. Cancer Res. 2006 May 15;66(10):5354-62. Cruet-Hennequart S, et al. UV-induced RPA phosphorylation is increased in the absence of DNA polymerase eta and requires DNA-PK. DNA Repair (Amst). 2006 Apr 8;5(4):491-504. Zhang B, Wu H, Hao J, et al. Inhibition of DNA-PKcs activity re-sensitizes uveal melanoma cells to radio-and chemotherapy. Biochemical and Biophysical Research Communications. 2019 Yang C, et al. NU7441 Enhances the Radiosensitivity of Liver Cancer Cells. Cell Physiol Biochem. 2016;38(5):1897-905.