WZ4003

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TargetMol
Product Code: TAR-T6291
Supplier: TargetMol
CodeSizePrice
TAR-T6291-5mg5mg£105.00
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Quantity:
TAR-T6291-1mL1 mL * 10 mM (in DMSO)£109.00
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Quantity:
TAR-T6291-10mg10mg£127.00
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Quantity:
TAR-T6291-25mg25mg£166.00
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Quantity:
TAR-T6291-50mg50mg£213.00
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Quantity:
TAR-T6291-100mg100mg£286.00
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Quantity:
TAR-T6291-200mg200mg£389.00
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Quantity:
TAR-T6291-500mg500mg£597.00
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Quantity:
Prices exclude any Taxes / VAT

Overview

Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃

Images

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Documents

Further Information

Bioactivity:
WZ4003, a highly selective NUAK kinase inhibitor, is with IC50 of 20 nM and 100 nM for NUAK1 and NUAK2, respectively. It is no significant inhibition on 139 other kinases.
CAS:
1214265-58-3
Formula:
C25H29ClN6O3
Molecular Weight:
497
Pathway:
Chromatin/Epigenetic; PI3K/Akt/mTOR signaling
Purity:
0.9801
SMILES:
CCC(=O)Nc1cccc(Oc2nc(Nc3ccc(cc3OC)N3CCN(C)CC3)ncc2Cl)c1
Target:
AMPK

References

Zhou W, et al. Nature. 2009, 462(7276), 1070-1074. Banerjee S, et al. Biochem J. 2014, 457(1), 215-225.