BIX02188

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TargetMol
Product Code: TAR-T6324
Supplier: TargetMol
CodeSizePrice
TAR-T6324-1mg1mg£105.00
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TAR-T6324-2mg2mg£119.00
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TAR-T6324-5mg5mg£173.00
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TAR-T6324-1mL1 mL * 10 mM (in DMSO)£188.00
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TAR-T6324-10mg10mg£264.00
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TAR-T6324-25mg25mg£362.00
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TAR-T6324-50mg50mg£508.00
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TAR-T6324-100mg100mg£701.00
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Quantity:
Prices exclude any Taxes / VAT

Overview

Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃

Images

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Documents

Further Information

Bioactivity:
BIX02188 is a specific MEK5 inhibitor (IC50: 4.3 nM), also inhibits ERK5 catalytic activity (IC50: 810 nM), and does not inhibit closely related kinases MEK1/2, JNK2, and ERK2.
CAS:
1094614-84-2
Formula:
C25H24N4O2
Molecular Weight:
412.48
Pathway:
MAPK; Stem Cells
Purity:
0.9921
SMILES:
CN(C)Cc1cccc(NC(c2ccccc2)=C2/C(=O)Nc3cc(ccc23)C(N)=O)c1
Target:
ERK; MEK; TGF-beta/Smad

References

Tatake RJ, et al. Biochem Biophys Res Commun, 2008, 377(1), 120-125. Li L, et al. Biochem Biophys Res Commun, 2008, 370(1), 159-163.