NNC-0640

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TargetMol
Product Code: TAR-T7364
Supplier: TargetMol
CodeSizePrice
TAR-T7364-1mg1mg£103.00
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TAR-T7364-2mg2mg£118.00
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TAR-T7364-1mL1 mL * 10 mM (in DMSO)£148.00
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TAR-T7364-5mg5mg£148.00
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TAR-T7364-10mg10mg£209.00
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TAR-T7364-25mg25mg£322.00
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TAR-T7364-50mg50mg£454.00
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TAR-T7364-100mg100mg£624.00
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Prices exclude any Taxes / VAT

Overview

Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃

Images

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Documents

Further Information

Bioactivity:
NNC-0640 is a negative allosteric modulator of Human Glucagon Receptor with an IC50 of 69.2 nM.
CAS:
307986-98-7
Formula:
C29H31N7O4S
Molecular Weight:
573.67
Pathway:
GPCR/G Protein
Purity:
0.98
SMILES:
CS(=O)(=O)c1cccc(NC(=O)N(Cc2ccc(cc2)C(=O)Nc2nn[nH]n2)c2ccc(cc2)C2CCCCC2)c1
Target:
Glucagon Receptor

References

Jazayeri A , Dor?, Andrew S, Lamb D , et al. Extra-helical binding site of a glucagon receptor antagonist[J]. Nature, 2016. Song G , Yang D , Wang Y , et al. Human GLP-1 receptor transmembrane domain structure in complex with allosteric modulators[J]. Nature, 2017.