Duocarmycin A
Code | Size | Price |
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TAR-T15180-5mg | 5mg | £850.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
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Further Information
Bioactivity:
Duocarmycin A, an antitumor antibiotic, is a DNA alkylator and efficiently alkylates adenine N3 at the 3? end of AT-rich sequences in the DNA. Duocarmycin A, as a chemotherapeutic agent, results in HLC-2 cells typically apoptotic changes.
CAS:
118292-34-5
Formula:
C26H25N3O8
Molecular Weight:
507.499
Pathway:
Apoptosis; Proteases/Proteasome
Purity:
0.98
SMILES:
[H][C@]12C[C@@]11C(=CC(=O)C3=C1C(=O)[C@@](C)(N3)C(=O)OC)N(C2)C(=O)c1cc2cc(OC)c(OC)c(OC)c2[nH]1
Target:
Caspase
References
1. Hirota M, et al. Distamycin A enhances the cytotoxicity of duocarmycin A and suppresses duocarmycin A-induced apoptosis in human lung carcinoma cells. Int J Biochem Cell Biol. 2007;39(5):988-96.