GANT 58

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TargetMol
Product Code: TAR-T15370
Supplier: TargetMol
CodeSizePrice
TAR-T15370-2mg2mg£96.00
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TAR-T15370-5mg5mg£109.00
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TAR-T15370-1mL1 mL * 10 mM (in DMSO)£118.00
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TAR-T15370-10mg10mg£132.00
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TAR-T15370-25mg25mg£205.00
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TAR-T15370-50mg50mg£283.00
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TAR-T15370-100mg100mg£412.00
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Prices exclude any Taxes / VAT

Overview

Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃

Images

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Documents

Further Information

Bioactivity:
GANT 58 is a potent antagonist of Gli. Which inhibits GLI1-induced transcription (IC50: 5 μM).
CAS:
64048-12-0
Formula:
C24H16N4S
Molecular Weight:
392.48
Pathway:
GPCR/G Protein; Stem Cells
Purity:
0.9988
SMILES:
c1cc(ccn1)-c1sc(c(c1-c1ccncc1)-c1ccncc1)-c1ccncc1
Target:
Hedgehog/Smoothened

References

1. Lauth M, et al. Inhibition of GLI-mediated transcription and tumor cell growth by small-molecule antagonists. Proc Natl Acad Sci U S A. 2007 May 15;104(20):8455-60. 2. Joo J, et al. GLI1 is a central mediator of EWS/FLI1 signaling in Ewing tumors. PLoS One. 2009 Oct 27;4(10):e7608.