Dynasore
Code | Size | Price |
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TAR-T1848-5mg | 5mg | £107.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T1848-10mg | 10mg | £128.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T1848-1mL | 1 mL * 10 mM (in DMSO) | £134.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T1848-25mg | 25mg | £185.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T1848-50mg | 50mg | £289.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T1848-100mg | 100mg | £386.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T1848-200mg | 200mg | £544.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T1848-500mg | 500mg | £817.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Images
Documents
Further Information
Bioactivity:
Dynasore, a cell-permeable chemical, can reversibly and non-competitivity inhibit GTPase activity of dynamin 1/2 (IC50: 15 μM in a cell-free assay). It also inhibits the mitochondrial dynamin Drp1, with no effect against other small GTPase.
CAS:
304448-55-3
Formula:
C18H14N2O4
Molecular Weight:
322.32
Pathway:
Autophagy; Microbiology/Virology; Cytoskeletal Signaling
Purity:
0.9989
SMILES:
Oc1ccc(C=NNC(=O)c2cc3ccccc3cc2O)cc1O
Target:
Dynamin; Virus Protease; Autophagy; HSV
References
1. Macia E, et al. Dev Cell, 2006, 10(6), 839-850.
2. Newton AJ, et al. Proc Natl Acad Sci USA, 2006, 103(47), 17955-17960.
3. Abban CY, et al. Am J Ther, 2008, 15(4), 304-311.
4. Li G, et al. Dynasore Improves Motor Function Recovery via Inhibition of Neuronal Apoptosis and Astrocytic Proliferation after Spinal Cord Injury in Rats. Mol Neurobiol. 2016 Nov 7.
5. Xu L L, Zhang X, Jiang Z Y, et al. Molecular similarity guided optimization of novel Nrf2 activators with 1, 2, 4-oxadiazole core[J]. Bioorganic & medicinal chemistry. 2016, 24(16): 3540-3547.
6. Wang X, Chen Q Z, Zan Y X, et al.?. Exosomal miR?145?5p derived from orthohantavirus?infected endothelial cells inhibits HTNV infection. The FASEB Journal. 2020, 34(10): 13809-13825.
7. Zhong B, Shi D, Wu F, et al. Dynasore suppresses cell proliferation, migration, and invasion and enhances the antitumor capacity of cisplatin via STAT3 pathway in osteosarcoma[J]. Cell death & disease. 2019, 10(10): 1-16.
8. Jiang K, Hou X, Tan T, et al. Scavenger receptor-C acts as a receptor for Bacillus thuringiensis vegetative insecticidal protein Vip3Aa and mediates the internalization of Vip3Aa via endocytosis[J]. PLoS pathogens. 2018 Oct 4;14(10):e1007347.
9. Zhang Y, Xue W, Zhang W, et al. Histone methyltransferase G9a protects against acute liver injury through GSTP1. Cell Death & Differentiation. 2019: 1-16.