Evoxine
| Code | Size | Price |
|---|
| TAR-T19854-5mg | 5mg | £1,235.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
Evoxine is a selective inhibitor of CO2-induced immune suppression. It inhibits hypercapnic suppression of interleukin-6 and the chemokine CCL2 expression in human THP-1 macrophages.
CAS:
522-11-2
Formula:
C18H21NO6
Molecular Weight:
347.37
Purity:
0.98
SMILES:
CC(O)(C)C(O)COC1=CC=C2C(OC)=C3C(OC=C3)=NC2=C1OC
References
1. Kouam ADK, Bissoue AN, Tcho AT, Happi EN, Waffo AFK, Sewald N, Wansi JD. Antimicrobial Furoquinoline Alkaloids from Vepris lecomteana (Pierre) Cheek & T. Heller (Rutaceae). Molecules. 2017 Dec 21;23(1). pii: E13. doi: 10.3390/molecules23010013. PubMed PMID: 29267257.
2. Helenius IT, Nair A, Bittar HE, Sznajder JI, Sporn PH, Beitel GJ. Focused Screening Identifies Evoxine as a Small Molecule That Counteracts CO2-Induced Immune Suppression. J Biomol Screen. 2016 Apr;21(4):363-71. doi: 10.1177/1087057115624091. Epub 2015 Dec 23. PubMed PMID: 26701099; PubMed Central PMCID: PMC5096368.
3. Kiplimo JJ, Islam MS, Koorbanally NA. A novel flavonoid and furoquinoline alkaloids from Vepris glomerata and their antioxidant activity. Nat Prod Commun. 2011 Dec;6(12):1847-50. PubMed PMID: 22312722.
4. Chu CC, Pan KL, Yao HT, Hsu JT. Development of a whole-cell screening system for evaluation of the human CYP1A2-mediated metabolism. Biotechnol Bioeng. 2011 Dec;108(12):2932-40. doi: 10.1002/bit.23256. Epub 2011 Aug 1. PubMed PMID: 21755496.