Cyclothialidine
Code | Size | Price |
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TAR-T23924-5mg | 5mg | £2,135.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T23924-50mg | 50mg | £4,231.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T23924-100mg | 100mg | £5,934.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Images
Documents
Further Information
Bioactivity:
Cyclothialidine is an inhibitor of DNA gyrase.
CAS:
147214-63-9
Formula:
C26H35N5O12S
Molecular Weight:
641.65
Purity:
0.98
SMILES:
C[C@H](NC(=O)[C@@H]1CSCc2c(O)cc(O)c(C)c2C(=O)OC[C@H](NC(=O)[C@@H]2[C@H](O)CCN2C(=O)[C@@H](N)CO)C(=O)N1)C(O)=O
References
1. Mayer C, Janin YL. Non-quinolone inhibitors of bacterial type IIA topoisomerases: a feat of bioisosterism. Chem Rev. 2014 Feb 26;114(4):2313-42. doi: 10.1021/cr4003984. Epub 2013 Dec 6. Review. PubMed PMID: 24313284.
2. Singh V, Chaudhary DK, Mani I. Gene network analysis of Aeromonas hydrophila for novel drug target discovery. Syst Synth Biol. 2012 Jun;6(1-2):23-30. doi: 10.1007/s11693-012-9093-z. Epub 2012 May 22. PubMed PMID: 23730361; PubMed Central PMCID: PMC3424198.
3. Singh SB, Young K, Miesel L. Screening strategies for discovery of antibacterial natural products. Expert Rev Anti Infect Ther. 2011 Aug;9(8):589-613. doi: 10.1586/eri.11.81. Review. PubMed PMID: 21819327.
4. Sa?z-Urra L, Cabrera P?rez M?, Helguera AM, Froeyen M. Combining molecular docking and QSAR studies for modelling the antigyrase activity of cyclothialidine derivatives. Eur J Med Chem. 2011 Jul;46(7):2736-47. doi: 10.1016/j.ejmech.2011.03.061. Epub 2011 Apr 5. PubMed PMID: 21530019.