JTH-601 free base
Code | Size | Price |
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TAR-T24220-5mg | 5mg | £850.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T24220-50mg | 50mg | £1,661.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T24220-100mg | 100mg | £2,079.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Images
Documents
Further Information
Bioactivity:
JTH-601 free base is an antagonist of alpha 1 adrenergic receptor.
CAS:
171277-06-8
Formula:
C24H35NO4
Molecular Weight:
401.547
Purity:
0.98
SMILES:
COc1c(C)c(C)c(O)c(C)c1CN(C)CCOc1cc(C)c(O)cc1C(C)C
References
1. Nobata K, Fujimura M, Ishiura Y, Hirose T, Furusyou S, Myou S, Kurashima K, Kasahara K, Nakao S. Alpha(1L)-, but not alpha(1H)-, adrenoceptor antagonist prevents allergic bronchoconstriction in guinea pigs in vivo. Eur J Pharmacol. 2002 Sep 27;452(1):97-104. PubMed PMID: 12323390.
2. Hirai T, Tsuru H, Tanimitsu N, Yajin K, Sasa M. Effect of JTH-601, a putative alpha(1L)-adrenoceptor antagonist, on guinea pig nasal mucosa vasculature. Eur J Pharmacol. 2001 Mar 23;416(1-2):141-4. PubMed PMID: 11282123.
3. Qiao X, Norota I, Endoh M. Pharmacological characteristics of inhibitory action of the selective alpha1-antagonist JTH-601 on the positive inotropic effect mediated by alpha1-adrenoceptors in isolated rabbit papillary muscle. Jpn J Pharmacol. 2000 Nov;84(3):301-9. PubMed PMID: 11138731.
4. Yamada S, Okura T, Kimura R, Deguchi Y, Suzuki Y, Kobayashi T, Aisaka K. Disposition and alpha(1)-adrenoceptor binding characteristics of JTH-601 and its metabolites in rat tissues. Drug Metab Dispos. 2000 Dec;28(12):1487-92. PubMed PMID: 11095588.