L 696418
| Code | Size | Price |
|---|
| TAR-T24344-5mg | 5mg | £930.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T24344-50mg | 50mg | £1,821.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T24344-100mg | 100mg | £2,319.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
L 696418 is a stromelysin inhibits.
CAS:
154096-58-9
Formula:
C25H33N3O4
Molecular Weight:
439.556
Purity:
0.98
SMILES:
CCC(N)C(=O)NC(=O)[C@H](CC(C)(C)c1ccccc1)N([C@@H](C)C(O)=O)c1ccccc1
References
1. Esser CK, Bugianesi RL, Caldwell CG, Chapman KT, Durette PL, Girotra NN, Kopka IE, Lanza TJ, Levorse DA, MacCoss M, Owens KA, Ponpipom MM, Simeone JP, Harrison RK, Niedzwiecki L, Becker JW, Marcy AI, Axel MG, Christen AJ, McDonnell J, Moore VL, Olszewski JM, Saphos C, Visco DM, Hagmann WK, et al. Inhibition of stromelysin-1 (MMP-3) by P1'-biphenylylethyl carboxyalkyl dipeptides. J Med Chem. 1997 Mar 14;40(6):1026-40. PubMed PMID: 9083493.
2. Bonassar LJ, Stinn JL, Paguio CG, Frank EH, Moore VL, Lark MW, Sandy JD, Hollander AP, Poole AR, Grodzinsky AJ. Activation and inhibition of endogenous matrix metalloproteinases in articular cartilage: effects on composition and biophysical properties. Arch Biochem Biophys. 1996 Sep 15;333(2):359-67. PubMed PMID: 8809074.
3. Garcia AM, Frank EH, Grimshaw PE, Grodzinsky AJ. Contributions of fluid convection and electrical migration to transport in cartilage: relevance to loading. Arch Biochem Biophys. 1996 Sep 15;333(2):317-25. PubMed PMID: 8809069.
4. Bonassar LJ, Jeffries KA, Frank EH, Moore VL, Lark MW, Bayne EK, McDonnell J, Olszewski J, Hagmann W, Chapman K, et al. In vivo effects of stromelysin on the composition and physical properties of rabbit articular cartilage in the presence and absence of a synthetic inhibitor. Arthritis Rheum. 1995 Nov;38(11):1678-86. PubMed PMID: 7488290.