Lysine-methotrexate
Code | Size | Price |
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TAR-T24427-5mg | 5mg | £850.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T24427-50mg | 50mg | £1,661.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T24427-100mg | 100mg | £2,079.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Images
Documents
Further Information
Bioactivity:
Lysine-methotrexate is an anticancer drug. It is an inhibitor of dihydrofolate reductase.
CAS:
80407-56-3
Formula:
C21H27N9O3
Molecular Weight:
453.507
Purity:
0.98
SMILES:
CN(Cc1cnc2nc(N)nc(N)c2n1)c1ccc(cc1)C(=O)N[C@@H](CCCCN)C(O)=O
References
1. Singh VK, Subudhi BB. Development and characterization of lysine-methotrexate conjugate for enhanced brain delivery. Drug Deliv. 2016 Sep;23(7):2327-2337. Epub 2014 Dec 5. PubMed PMID: 25475953.
2. D?az E, K?hidai L, R?os A, Vanegas O, Silva A, Szab? R, Mez? G, Hudecz F, Ponte-Sucre A. Leishmania braziliensis: cytotoxic, cytostatic and chemotactic effects of poly-lysine-methotrexate-conjugates. Exp Parasitol. 2013 Sep;135(1):134-41. doi: 10.1016/j.exppara.2013.06.007. Epub 2013 Jun 28. PubMed PMID: 23816643.
3. Kempton RJ, Black AM, Anstead GM, Kumar AA, Blankenship DT, Freisheim JH. Lysine and ornithine analogues of methotrexate as inhibitors of dihydrofolate reductase. J Med Chem. 1982 Apr;25(4):475-7. PubMed PMID: 7069726.