Malonganenone A
| Code | Size | Price |
|---|
| TAR-T24429-5mg | 5mg | £850.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
Malonganenone A is a selective plasmodial Hsp70s modulator. It also has antimalarial activity.
CAS:
882403-69-2
Formula:
C26H38N4O2
Molecular Weight:
438.616
Purity:
0.98
SMILES:
CC(C)CC(=O)C=C(C)CCCC(C)=CCCC(C)=CCn1cnc2n(C)cnc(=O)c12
References
1. Cockburn IL, Boshoff A, Pesce ER, Blatch GL. Selective modulation of plasmodial Hsp70s by small molecules with antimalarial activity. Biol Chem. 2014 Nov 1;395(11):1353-62. doi: 10.1515/hsz-2014-0138. PubMed PMID: 24854538.
2. Clark PG, Lein M, Keyzers RA. Studies of the H-D exchange mechanism of malonganenone B. Org Biomol Chem. 2012 Mar 7;10(9):1725-9. doi: 10.1039/c2ob06926a. Epub 2012 Jan 16. PubMed PMID: 22246312.
3. Cockburn IL, Pesce ER, Pryzborski JM, Davies-Coleman MT, Clark PG, Keyzers RA, Stephens LL, Blatch GL. Screening for small molecule modulators of Hsp70 chaperone activity using protein aggregation suppression assays: inhibition of the plasmodial chaperone PfHsp70-1. Biol Chem. 2011 May;392(5):431-8. doi: 10.1515/BC.2011.040. Epub 2011 Mar 23. PubMed PMID: 21426241.