Rimcazole
| Code | Size | Price |
|---|
| TAR-T24712-5mg | 5mg | £850.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T24712-50mg | 50mg | £1,661.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T24712-100mg | 100mg | £2,079.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
Rimcazole is a sigma receptor antagonist. It also binds to the dopamine transporter and inhibiting dopamine uptake.
CAS:
75859-04-0
Formula:
C21H27N3
Molecular Weight:
321.468
Purity:
0.98
SMILES:
C[C@H]1CN(CCCn2c3ccccc3c3ccccc23)C[C@@H](C)N1
References
1. Jayant RD, Atluri VSR, Tiwari S, Pilakka-Kanthikeel S, Kaushik A, Yndart A, Nair M. Novel nanoformulation to mitigate co-effects of drugs of abuse and HIV-1 infection: towards the treatment of NeuroAIDS. J Neurovirol. 2017 Aug;23(4):603-614. doi: 10.1007/s13365-017-0538-8. Epub 2017 Jul 31. PubMed PMID: 28762183; PubMed Central PMCID: PMC5623083.
2. DeLarge AF, Erwin LL, Winsauer PJ. Atypical binding at dopamine and serotonin transporters contribute to the discriminative stimulus effects of mephedrone. Neuropharmacology. 2017 Jun;119:62-75. doi: 10.1016/j.neuropharm.2017.04.006. Epub 2017 Apr 7. PubMed PMID: 28396142.
3. Kaushik A, Vabbina PK, Atluri V, Shah P, Vashist A, Jayant RD, Yandart A, Nair M. Electrochemical monitoring-on-chip (E-MoC) of HIV-infection in presence of cocaine and therapeutics. Biosens Bioelectron. 2016 Dec 15;86:426-431. doi: 10.1016/j.bios.2016.06.086. Epub 2016 Jun 29. PubMed PMID: 27419908; PubMed Central PMCID: PMC5028277.
4. Happy M, Dejoie J, Zajac CK, Cortez B, Chakraborty K, Aderemi J, Sauane M. Sigma 1 Receptor antagonist potentiates the anti-cancer effect of p53 by regulating ER stress, ROS production, Bax levels, and caspase-3 activation. Biochem Biophys Res Commun. 2015 Jan 9;456(2):683-8. doi: 10.1016/j.bbrc.2014.12.029. Epub 2014 Dec 13. PubMed PMID: 25511708.