ROCK-IN-D3
| Code | Size | Price |
|---|
| TAR-T24725-5mg | 5mg | £850.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T24725-50mg | 50mg | £1,661.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T24725-100mg | 100mg | £2,079.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
ROCK-IN-D3 is an effective and selective inhibitor of ROCK.
CAS:
1219727-16-8
Formula:
C20H22N4O
Molecular Weight:
334.423
Purity:
0.98
SMILES:
CC(C)N(Cc1ccccc1)C(=O)Nc1ccc(cc1)-c1cn[nH]c1
References
1. Rasche L, Chavan SS, Stephens OW, Patel PH, Tytarenko R, Ashby C, Bauer M, Stein C, Deshpande S, Wardell C, Buzder T, Molnar G, Zangari M, van Rhee F, Thanendrarajan S, Schinke C, Epstein J, Davies FE, Walker BA, Meissner T, Barlogie B, Morgan GJ, Weinhold N. Spatial genomic heterogeneity in multiple myeloma revealed by multi-region sequencing. Nat Commun. 2017 Aug 16;8(1):268. doi: 10.1038/s41467-017-00296-y. PubMed PMID: 28814763; PubMed Central PMCID: PMC5559527.
2. Liu K, Sun Y, Liu D, Ye S. Inhibition of Wnt/?-catenin signaling by IWR1 induces expression of Foxd3 to promote mouse epiblast stem cell self-renewal. Biochem Biophys Res Commun. 2017 Aug 26;490(3):616-622. doi: 10.1016/j.bbrc.2017.06.086. Epub 2017 Jun 16. PubMed PMID: 28630002.
3. Chen Y, Huang W, Jiang W, Wu X, Ye B, Zhou X. HIV-1 Tat Regulates Occludin and A? Transfer Receptor Expression in Brain Endothelial Cells via Rho/ROCK Signaling Pathway. Oxid Med Cell Longev. 2016;2016:4196572. doi: 10.1155/2016/4196572. Epub 2016 Aug 2. PubMed PMID: 27563375; PubMed Central PMCID: PMC4985576.
4. Paintlia AS, Paintlia MK, Hollis BW, Singh AK, Singh I. Interference with RhoA-ROCK signaling mechanism in autoreactive CD4+ T cells enhances the bioavailability of 1,25-dihydroxyvitamin D3 in experimental autoimmune encephalomyelitis. Am J Pathol. 2012 Sep;181(3):993-1006. doi: 10.1016/j.ajpath.2012.05.028. Epub 2012 Jul 13. PubMed PMID: 22796435; PubMed Central PMCID: PMC3432427.