ROR Modulator I
| Code | Size | Price |
|---|
| TAR-T24727-5mg | 5mg | £850.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T24727-50mg | 50mg | £1,661.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T24727-100mg | 100mg | £2,079.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
ROR Modulator I is the first potent inverse agonist of the retinoid-related orphan receptor. It also has dual selectivity for RORβ and RORγt.
CAS:
1361413-10-6
Formula:
C26H20Cl2N2O4S2
Molecular Weight:
559.48
Purity:
0.98
SMILES:
CCS(=O)(=O)c1ccc(CC(=O)Nc2nc(c(s2)C(=O)c2ccccc2Cl)-c2cccc(Cl)c2)cc1
References
1. Lee J, Lee S, Chung S, Park N, Son GH, An H, Jang J, Chang DJ, Suh YG, Kim K. Identification of a novel circadian clock modulator controlling BMAL1 expression through a ROR/REV-ERB-response element-dependent mechanism. Biochem Biophys Res Commun. 2016 Jan 15;469(3):580-6. doi: 10.1016/j.bbrc.2015.12.030. Epub 2015 Dec 12. PubMed PMID: 26692477.
2. Toyama H, Sato S, Shirakawa H, Komai M, Hashimoto Y, Fujii S. Altered activity profile of a tertiary silanol analog of multi-targeting nuclear receptor modulator T0901317. Bioorg Med Chem Lett. 2016 Apr 1;26(7):1817-20. doi: 10.1016/j.bmcl.2016.02.031. Epub 2016 Feb 12. PubMed PMID: 26905831.
3. Ding FM, Liao RM, Chen YQ, Xie GG, Zhang PY, Shao P, Zhang M. Upregulation of SOCS3 in lung CD4+ T cells in a mouse model of chronic PA lung infection and suppression of Th17 mediated neutrophil recruitment in exogenous SOCS3 transfer in vitro. Mol Med Rep. 2017 Jul;16(1):778-786. doi: 10.3892/mmr.2017.6630. Epub 2017 May 25. PubMed PMID: 28560450; PubMed Central PMCID: PMC5482193.
4. Astafev AA, Patel SA, Kondratov RV. Calorie restriction effects on circadian rhythms in gene expression are sex dependent. Sci Rep. 2017 Aug 29;7(1):9716. doi: 10.1038/s41598-017-09289-9. PubMed PMID: 28851928; PubMed Central PMCID: PMC5575277.