8-Deazafolic acid
Code | Size | Price |
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TAR-T24990-5mg | 5mg | £1,332.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T24990-50mg | 50mg | £2,625.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T24990-100mg | 100mg | £3,524.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Images
Documents
Further Information
Bioactivity:
8-Deazafolic acid is a potent folate-dependent bacteria inhibitor, Streptococcus faecium (ATCC 8043) and Lactobacillus casei (ATCC 7469), and to have activity against lymphoid leukemia L1210 in mice.
CAS:
51989-25-4
Formula:
C20H20N6O6
Molecular Weight:
440.416
Purity:
0.98
SMILES:
Nc1nc(=O)c2nc(CNc3ccc(cc3)C(=O)N[C@@H](CCC(O)=O)C(O)=O)ccc2[nH]1
References
1. Temple C Jr, Kussner CL, Rose JD, Smithers DL, Bennett LL Jr, Montgomery JA. New synthesis of N-[4-[[(2-amino-4(3H)-oxopyrido[3,2-d]pyrimidin-6-yl)methyl]amino]benzoyl]-L-glut amic acid (8-deazafolic acid) and the preparation of some 5,6,7,8-tetrahydro derivatives. J Med Chem. 1981 Oct;24(10):1254-8. PubMed PMID: 6948961.
2. Oatis JE Jr, Hynes JB. Sycnthesis of quinazoline analogues of folic acid modified at postion 10. J Med Chem. 1977 Nov;20(11):1393-6. PubMed PMID: 915899.
3. Hynes JB, Eason DE, Garrett CM, Colvin PL Jr. Quinazolines as inhibitors of dihydrofolate reductase. 4. Classical analogues of folic and isofolic acids. J Med Chem. 1977 Apr;20(4):588-91. PubMed PMID: 850245.
4. DeGraw JI, Kisliuk RL, Gaumont Y, Baugh CM. Antimicrobial activity of 8-deazafolic acid. J Med Chem. 1974 Apr;17(4):470-1. PubMed PMID: 4208536.