Abieslactone
| Code | Size | Price |
|---|
| TAR-T24996-5mg | 5mg | £850.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
Abieslacton possesses anti-tumor promoting activity isolated from several Abies genus.
CAS:
33869-93-1
Formula:
C31H48O4
Molecular Weight:
484.721
Purity:
0.98
SMILES:
[H][C@]12CC[C@]3(C)[C@@H]4CC[C@@]3(C)C1=CC[C@@]1([H])[C@@](C)(COC(=O)C(C)=C/[C@H](O)C[C@H]4C)[C@@H](CC[C@]21C)OC
References
1. Wang GW, Lv C, Shi ZR, Zeng RT, Dong XY, Zhang WD, Liu RH, Shan L, Shen YH. Abieslactone induces cell cycle arrest and apoptosis in human hepatocellular carcinomas through the mitochondrial pathway and the generation of reactive oxygen species. PLoS One. 2014 Dec 11;9(12):e115151. doi: 10.1371/journal.pone.0115151. eCollection 2014. PubMed PMID: 25502685; PubMed Central PMCID: PMC4263740.
2. Takayasu J, Tanaka R, Matsunaga S, Ueyama H, Tokuda H, Hasegawa T, Nishino A, Nishino H, Iwashima A. Anti-tumor-promoting activity of derivatives of abieslactone, a natural triterpenoid isolated from several Abies genus. Cancer Lett. 1990 Sep;53(2-3):141-4. PubMed PMID: 2208073.
3. UYEO S, OKADA J, MATSUNAGO S. [SELENIUM DEHYDROGENATION OF ABIESLACTONE]. Yakugaku Zasshi. 1964 May;84:453-7. Japanese. PubMed PMID: 14193916.
4. Iwai S, Wei M, Morimura K, Wanibuchi H, Tanaka R, Matsunaga S, Yoshitake A, Seki S, Fukushima S. Possible prevention by abieslactone of development of diethylnitrosamine-initiated GST-P positive foci in the rat liver. Teratog Carcinog Mutagen. 2001;21(3):223-9. PubMed PMID: 11301417.