ABT-510 acetate

TargetMol
Product Code: TAR-T24997
Supplier: TargetMol
CodeSizePrice
TAR-T24997-1mg1mg£114.00
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TAR-T24997-5mg5mg£173.00
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TAR-T24997-10mg10mg£226.00
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TAR-T24997-25mg25mg£333.00
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Quantity:
TAR-T24997-50mg50mg£463.00
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Quantity:
TAR-T24997-100mg100mg£643.00
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Prices exclude any Taxes / VAT

Overview

Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃

Images

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Further Information

Bioactivity:
ABT-510 acetate is a synthetic analog of thrombospondin (an endogenous angiogenesis inhibitor).
CAS:
442526-87-6
Formula:
C48H87N13O13
Molecular Weight:
1054.302
Pathway:
Apoptosis
Purity:
0.98
SMILES:
CC(O)=O.CCC[C@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@@H](NC(=O)CNC(=O)CN(C)C(C)=O)C(C)C)[C@@H](C)CC)[C@@H](C)O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)NCC
Target:
Apoptosis

References

1. Uronis HE, Cushman SM, Bendell JC, Blobe GC, Morse MA, Nixon AB, Dellinger A, Starr MD, Li H, Meadows K, Gockerman J, Pang H, Hurwitz HI. A phase I study of ABT-510 plus bevacizumab in advanced solid tumors. Cancer Med. 2013 Jun;2(3):316-24. doi: 10.1002/cam4.65. Epub 2013 Mar 21. PubMed PMID: 23930208; PubMed Central PMCID: PMC3699843. 2. Matsumoto E, Fujita Y, Okada Y, Kauppinen EI, Kamiya H, Chiba K. Hydrophobic benzyl amines as supports for liquid-phase C-terminal amidated peptide synthesis: application to the preparation of ABT-510. J Pept Sci. 2015 Sep;21(9):691-5. doi: 10.1002/psc.2791. Epub 2015 Jul 22. PubMed PMID: 26200065. 3. Recouvreux MV, Camilletti MA, Rifkin DB, Becu-Villalobos D, D?az-Torga G. Thrombospondin-1 (TSP-1) analogs ABT-510 and ABT-898 inhibit prolactinoma growth and recover active pituitary transforming growth factor-?1 (TGF-?1). Endocrinology. 2012 Aug;153(8):3861-71. doi: 10.1210/en.2012-1007. Epub 2012 Jun 14. PubMed PMID: 22700773; PubMed Central PMCID: PMC3404347. 4. Sahora AI, Rusk AW, Henkin J, McKeegan EM, Shi Y, Khanna C. Prospective study of thrombospondin-1 mimetic peptides, ABT-510 and ABT-898, in dogs with soft tissue sarcoma. J Vet Intern Med. 2012 Sep-Oct;26(5):1169-76. doi: 10.1111/j.1939-1676.2012.00966.x. Epub 2012 Jul 21. PubMed PMID: 22816494.