Aklanonic acid
| Code | Size | Price |
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| TAR-T25013-5mg | 5mg | £850.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
Aklanonic acid is an intermediate in the biosynthesis of anthracycline antibiotics from Streptomyces sp. ZIMET 43717.
CAS:
91432-47-2
Formula:
C21H16O8
Molecular Weight:
396.351
Purity:
0.98
SMILES:
CCC(=O)C=C(/O)c1c(CC(O)=O)cc2C(=O)c3cccc(O)c3C(=O)c2c1O
References
1. Castaldo G, Zucko J, Heidelberger S, Vujaklija D, Hranueli D, Cullum J, Wattana-Amorn P, Crump MP, Crosby J, Long PF. Proposed arrangement of proteins forming a bacterial type II polyketide synthase. Chem Biol. 2008 Nov 24;15(11):1156-65. doi: 10.1016/j.chembiol.2008.09.010. PubMed PMID: 19022176.
2. Kallio P, Sultana A, Niemi J, M?nts?l? P, Schneider G. Crystal structure of the polyketide cyclase AknH with bound substrate and product analogue: implications for catalytic mechanism and product stereoselectivity. J Mol Biol. 2006 Mar 17;357(1):210-20. Epub 2006 Jan 6. PubMed PMID: 16414075.
3. Lee TS, Khosla C, Tang Y. Engineered biosynthesis of aklanonic acid analogues. J Am Chem Soc. 2005 Sep 7;127(35):12254-62. PubMed PMID: 16131203; PubMed Central PMCID: PMC1343498.
4. Chung JY, Fujii I, Harada S, Sankawa U, Ebizuka Y. Expression, purification, and characterization of AknX anthrone oxygenase, which is involved in aklavinone biosynthesis in Streptomyces galilaeus. J Bacteriol. 2002 Nov;184(22):6115-22. PubMed PMID: 12399480; PubMed Central PMCID: PMC151955.