GS-9191
Code | Size | Price |
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TAR-T25466-1mg | 1mg | £215.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T25466-5mg | 5mg | £432.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T25466-1mL | 1 mL * 10 mM (in DMSO) | £595.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T25466-10mg | 10mg | £603.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T25466-25mg | 25mg | £863.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T25466-50mg | 50mg | £1,187.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T25466-100mg | 100mg | £1,581.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T25466-500mg | 500mg | £3,115.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Images
Documents
Further Information
Bioactivity:
GS-9191 is a novel antipapillomavirus drug.
CAS:
859209-84-0
Formula:
C37H51N8O5P
Molecular Weight:
718.84
Pathway:
DNA Damage/DNA Repair|Cell Cycle/Checkpoint
Purity:
0.98
SMILES:
CC(C)COC(=O)[C@H](Cc1ccccc1)NP(COCCn1cnc2c(NC3CC3)nc(N)nc12)N[C@@H](Cc1ccccc1)C(=O)OCC(C)C
Target:
DNA/RNA Synthesis
References
1. Birkus G, Kutty N, Frey CR, Shribata R, Chou T, Wagner C, McDermott M, Cihlar T. Role of cathepsin A and lysosomes in the intracellular activation of novel antipapillomavirus agent GS-9191. Antimicrob Agents Chemother. 2011 May;55(5):2166-73. doi: 10.1128/AAC.01603-10. Epub 2011 Mar 7. PubMed PMID: 21383096; PubMed Central PMCID: PMC3088193.
2. Wolfgang GH, Shibata R, Wang J, Ray AS, Wu S, Doerrfler E, Reiser H, Lee WA, Birkus G, Christensen ND, Andrei G, Snoeck R. GS-9191 is a novel topical prodrug of the nucleotide analog 9-(2-phosphonylmethoxyethyl)guanine with antiproliferative activity and possible utility in the treatment of human papillomavirus lesions. Antimicrob Agents Chemother. 2009 Jul;53(7):2777-84. doi: 10.1128/AAC.00103-09. Epub 2009 Apr 27. PubMed PMID: 19398642; PubMed Central PMCID: PMC2704673.
3. De Clercq E. Dancing with chemical formulae of antivirals: a personal account. Biochem Pharmacol. 2013 Sep 15;86(6):711-25. doi: 10.1016/j.bcp.2013.07.012. Epub 2013 Jul 19. Review. PubMed PMID: 23876344.
4. Rai MA, Pannek S, Fichtenbaum CJ. Emerging reverse transcriptase inhibitors for HIV-1 infection. Expert Opin Emerg Drugs. 2018 Jun;23(2):149-157. doi: 10.1080/14728214.2018.1474202. Epub 2018 May 10. PubMed PMID: 29737220.