Thr8-saralasin
| Code | Size | Price |
|---|
| TAR-T26274-5mg | 5mg | £850.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
Thr8-saralasin is an angiotensin antagonist.
CAS:
74127-89-2
Formula:
C43H67N13O11
Molecular Weight:
942.089
Purity:
0.98
SMILES:
CNCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C[C@@H]1C=NC=N1)C(=O)OC(=O)[C@@H](NC(=O)[C@@H]1CCCN1)[C@@H](C)O
References
1. Bravo EL, Khosla MC, Bumpus FM. Comparative studies of the humoral and arterial pressure responses to Sar1-Ala8-, Sar1-Ile8 and Sar1-Thr8-angiotensin II in the trained unanaesthetized dog. Prog Biochem Pharmacol. 1976;12:33-40. PubMed PMID: 1019168.
2. Mu?oz-Ram?rez H, Khosla MC, Bumpus FM, Khairallah PA. Hypotensive effect of [Sar1,Thr8]angiotensin II in spontaneously hypertensive sodium-depleted rats. Am J Physiol. 1978 Apr;234(4):H447-53. PubMed PMID: 645884.
3. Hata T, Ogihara T, Nakamaru M, Gotoh S, Masuo K, Saeki S, Kumagai A, Kumahara Y. Effect of three angiotensin II antagonists, [Sar1, Thr8]-, [Sar1, Ile8]- and [Sar1, Ala8]angiotensin II on blood pressure and endocrine factors in normal subjects. Eur J Clin Pharmacol. 1982;23(1):7-10. PubMed PMID: 6751836.
4. Stefas L, Levy BI. Effects of saralasin on arterial compliance in normotensive and hypertensive rats. Role of endothelium. Hypertension. 1991 Oct;18(4 Suppl):II30-6. PubMed PMID: 1916999.