6-Benzylthioinosine
| Code | Size | Price |
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| TAR-T26395-5mg | 5mg | £850.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
6-Benzylthioinosine, a broad-spectrum metabolic inhibitor, inhibits glucose uptake, decreases glycolysis and ATP concentration with minimal changes in ROS and mitochondrial respiration.
CAS:
6165-03-3
Formula:
0
Molecular Weight:
0
Purity:
0.98
SMILES:
0
References
1. Sabnis HS, Bradley HL, Tripathi S, Yu WM, Tse W, Qu CK, Bunting KD. Synergistic cell death in FLT3-ITD positive acute myeloid leukemia by combined treatment with metformin and 6-benzylthioinosine. Leuk Res. 2016 Nov;50:132-140. doi: 10.1016/j.leukres.2016.10.004. Epub 2016 Oct 5. PubMed PMID: 27760406; PubMed Central PMCID: PMC5083204.
2. Zang S, Liu N, Wang H, Wald DN, Shao N, Zhang J, Ma D, Ji C, Tse W. Wnt signaling is involved in 6-benzylthioinosine-induced AML cell differentiation. BMC Cancer. 2014 Nov 27;14:886. doi: 10.1186/1471-2407-14-886. PubMed PMID: 25428027; PubMed Central PMCID: PMC4289047.
3. Chakrabarti A, Gupta K, Sharma JP, Yang J, Agarwal A, Glick A, Zhang Y, Agarwal M, Agarwal MK, Wald DN. ATP depletion triggers acute myeloid leukemia differentiation through an ATR/Chk1 protein-dependent and p53 protein-independent pathway. J Biol Chem. 2012 Jul 6;287(28):23635-43. doi: 10.1074/jbc.M111.312801. Epub 2012 May 23. PubMed PMID: 22621920; PubMed Central PMCID: PMC3390638.
4. Al Safarjalani ON, Rais RH, Kim YA, Chu CK, Naguib FN, El Kouni MH. Carbocyclic 6-benzylthioinosine analogues as subversive substrates of Toxoplasma gondii adenosine kinase: biological activities and selective toxicities. Biochem Pharmacol. 2010 Oct 1;80(7):955-63. doi: 10.1016/j.bcp.2010.06.001. Epub 2010 Jun 10. PubMed PMID: 20541538; PubMed Central PMCID: PMC2923275.