BN 50739
Code | Size | Price |
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TAR-T26875-5mg | 5mg | £1,171.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T26875-50mg | 50mg | £2,303.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T26875-100mg | 100mg | £3,042.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Images
Documents
Further Information
Bioactivity:
BN 50739 is an antagonist of platelet-activating factor (PAF). BN 50739 suppresses certain cardiac arrhythmias. PAF is released from ischaemic myocardium and may contribute to initiation of ischaemia-induced ventricular fibrillation (VF)
CAS:
128672-07-1
Formula:
C28H26ClN5O2S3
Molecular Weight:
596.18
Purity:
0.98
SMILES:
COc1ccc(SCC(=S)N2CCc3c(C2)sc-2c3C(=NCc3nnc(C)n-23)c2ccccc2Cl)cc1OC
References
1. Baker KE, Curtis MJ. Protection against ventricular fibrillation by the PAF antagonist, BN-50739, involves an ischaemia-selective mechanism. J Cardiovasc Pharmacol. 1999 Sep;34(3):394-401. PubMed PMID: 10470998.
2. Kintner DB, Fitzpatrick JH Jr, Gilboe DD. Hyperglycemic damage to mitochondrial membranes during cerebral ischemia: amelioration by platelet-activating factor antagonist BN 50739. J Neurochem. 1997 Sep;69(3):1219-27. PubMed PMID: 9282946.
3. Sun D, Gilboe DD. Effect of the platelet-activating factor antagonist BN 50739 and its diluents on mitochondrial respiration and membrane lipids during and following cerebral ischemia. J Neurochem. 1994 May;62(5):1929-38. PubMed PMID: 8158141.
4. Ranaut K, Singh M. BN-50739: a PAF antagonist and limitation of myocardial infarct size. Methods Find Exp Clin Pharmacol. 1993 Jan-Feb;15(1):9-14. PubMed PMID: 8479250.