CRX-526
| Code | Size | Price |
|---|
| TAR-T27090-5mg | 5mg | Enquire | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
CRX-526, a TLR4 antagonist, protects against advanced diabetic nephropathy.
CAS:
245515-64-4
Formula:
C69H127N2O19P
Molecular Weight:
1319.744
Purity:
0.98
SMILES:
CCCCCCCCCCC[C@H](CC(=O)N[C@@H](CO[C@@H]1O[C@H](CO)[C@@H](OP(O)(O)=O)[C@H](OC(=O)C[C@@H](CCCCCCCCCCC)OC(=O)CCCCC)[C@H]1NC(=O)C[C@@H](CCCCCCCCCCC)OC(=O)CCCCC)C(O)=O)OC(=O)CCCCC
References
1. Wang H, Gu J, Hou X, Chen J, Yang N, Liu Y, Wang G, Du M, Qiu H, Luo Y, Jiang Z, Feng L. Anti-inflammatory effect of miltirone on inflammatory bowel disease via TLR4/NF-?B/IQGAP2 signaling pathway. Biomed Pharmacother. 2017 Jan;85:531-540. doi: 10.1016/j.biopha.2016.11.061. Epub 2016 Nov 27. PubMed PMID: 27903427.
2. Zhou J, Soltow M, Zimmermann K, Pavlovic D, Johnston B, Lehmann C. Experimental TLR4 inhibition improves intestinal microcirculation in endotoxemic rats. Microvasc Res. 2015 Sep;101:33-7. doi: 10.1016/j.mvr.2015.06.004. Epub 2015 Jun 24. PubMed PMID: 26116862.
3. Huang HY, Zhang ZJ, Cao CB, Wang N, Liu FF, Peng JQ, Ren XJ, Qian J. The TLR4/NF-?B signaling pathway mediates the growth of colon cancer. Eur Rev Med Pharmacol Sci. 2014;18(24):3834-43. PubMed PMID: 25555874.
4. Lin M, Yiu WH, Li RX, Wu HJ, Wong DW, Chan LY, Leung JC, Lai KN, Tang SC. The TLR4 antagonist CRX-526 protects against advanced diabetic nephropathy. Kidney Int. 2013 May;83(5):887-900. doi: 10.1038/ki.2013.11. Epub 2013 Feb 20. PubMed PMID: 23423259.