Dihydrocelastrol
| Code | Size | Price |
|---|
| TAR-T27174-5mg | 5mg | £309.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
Dihydrocelastrol is synthesized by hydrogenation of celastrol, a treterpene isolated from Chinese medicinal plant Tripterygium regelii. Dihydrocelastrol could inhibit cell proliferation and promote apoptosis through caspase-dependent way in vitro. DHCE could inhibit cellular proliferation and induce cell apoptosis in myeloma cells mediated through different mechanisms, possibly through inhibiting the ERK1/2 and IL-6/STAT3 pathways.
CAS:
193957-88-9
Formula:
C29H40O4
Molecular Weight:
452.635
Purity:
0.98
SMILES:
Cc1c(O)c(O)cc2c1CC=C1[C@@]2(C)CC[C@@]2(C)[C@@H]3C[C@@](C)(CC[C@]3(C)CC[C@]12C)C(O)=O
References
1. Woo SG, Lee SM, Lee SY, Lim KH, Ha EJ, Kim SH, Eom YB. The effectiveness of anti-biofilm and anti-virulence properties of dihydrocelastrol and dihydrocelastryl diacetate in fighting against methicillin-resistant Staphylococcus aureus. Arch Microbiol. 2017 May 9. doi: 10.1007/s00203-017-1386-x. [Epub ahead of print] PubMed PMID: 28487997.
2. Hu L, Wu H, Li B, Song D, Yang G, Chen G, Xie B, Xu Z, Zhang Y, Yu D, Hou J, Xiao W, Sun X, Chang G, Zhang Y, Gao L, Dai B, Tao Y, Shi J, Zhu W. Dihydrocelastrol inhibits multiple myeloma cell proliferation and promotes apoptosis through ERK1/2 and IL-6/STAT3 pathways in vitro and in vivo. Acta Biochim Biophys Sin (Shanghai). 2017 May 1;49(5):420-427. doi: 10.1093/abbs/gmx021. PubMed PMID: 28338993.
3. Fribley AM, Miller JR, Brownell AL, Garshott DM, Zeng Q, Reist TE, Narula N, Cai P, Xi Y, Callaghan MU, Kodali V, Kaufman RJ. Celastrol induces unfolded protein response-dependent cell death in head and neck cancer. Exp Cell Res. 2015 Jan 15;330(2):412-22. doi: 10.1016/j.yexcr.2014.08.014. Epub 2014 Aug 17. PubMed PMID: 25139619; PubMed Central PMCID: PMC4280347.
4. Seo HR, Seo WD, Pyun BJ, Lee BW, Jin YB, Park KH, Seo EK, Lee YJ, Lee YS. Radiosensitization by celastrol is mediated by modification of antioxidant thiol molecules. Chem Biol Interact. 2011 Aug 15;193(1):34-42. doi: 10.1016/j.cbi.2011.04.009. Epub 2011 May 4. PubMed PMID: 21570383.