FR 110302
| Code | Size | Price |
|---|
| TAR-T27359-5mg | 5mg | £850.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T27359-50mg | 50mg | £1,661.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T27359-100mg | 100mg | £2,079.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
FR 110302 is a potent inhibitor of 5-lipoxygenase.
CAS:
119256-94-9
Formula:
C28H35NO2
Molecular Weight:
417.593
Purity:
0.98
SMILES:
CCCCC1(CCCC)CCc2c(OCc3ccc4ccccc4n3)cccc2[C@H]1O
References
1. Yatabe T, Kayakiri H, Kawai Y, Oku T, Tanaka H. Studies on 5-lipoxygenase inhibitors. II. Discovery, optical resolution and enantioselective synthesis of FR110302, a highly potent non-redox type 5-lipoxygenase inhibitor. Chem Pharm Bull (Tokyo). 1998 Oct;46(10):1556-65. PubMed PMID: 9810693.
2. Negro JM, Miralles JC, Ortiz JL, Funes E, Garc?a A. Biosynthesis inhibitors for leukotrienes in bronchial asthma. Allergol Immunopathol (Madr). 1997 Jul-Aug;25(4):209-16. Review. PubMed PMID: 9269512.
3. Asano M, Imai T, Inoue H, Masunaga T, Inamura N, Yatabe T, Hiroi J, Nakahara K, Notsu Y, Takishima T. A 5-lipoxygenase inhibitor, FR110302, inhibits ozone-induced airway hyperresponsiveness in guinea pigs and dogs. Agents Actions. 1993 Mar;38(3-4):171-7. PubMed PMID: 8213343.
4. Asano M, Inamura N, Nakahara K, Nagayoshi A, Isono T, Hamada K, Oku T, Notsu Y, Kohsaka M, Ono T. A 5-lipoxygenase inhibitor, FR110302, suppresses airway hyperresponsiveness and lung eosinophilia induced by Sephadex particles in rats. Agents Actions. 1992 Jul;36(3-4):215-21. PubMed PMID: 1382375.