HIE-124
| Code | Size | Price |
|---|
| TAR-T27543-5mg | 5mg | £850.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T27543-50mg | 50mg | £1,661.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T27543-100mg | 100mg | £2,079.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
HIE-124 is a central cervous system active anticonvulsant and ultra-short acting hypnotic.
CAS:
805326-00-5
Formula:
C10H12N2O3S
Molecular Weight:
240.28
Purity:
0.98
SMILES:
CCOC(=O)C1=CSC2=NC(=O)CCCN12
References
1. El-Subbagh HI, El-Azab AS, Hassan GS, El-Messery SM, Abdel-Aziz AA, El-Taher KE. Thiadiazolodiazepine analogues as a new class of neuromuscular blocking agents: Synthesis, biological evaluation and molecular modeling study. Eur J Med Chem. 2017 Jan 27;126:15-23. doi: 10.1016/j.ejmech.2016.09.096. Epub 2016 Sep 30. PubMed PMID: 27744183.
2. El-Subbagh HI, Hassan GS, El-Taher KE, El-Messery SM, Al-Azab AS, Abdelaziz AA, Hefnawy MM. Synthesis, biological evaluation and molecular modeling study of thiadiazolo[3,2-a][1,3]diazepine analogues of HIE-124 as a new class of short acting hypnotics. Eur J Med Chem. 2016 Nov 29;124:237-247. doi: 10.1016/j.ejmech.2016.08.038. Epub 2016 Aug 22. PubMed PMID: 27597405.
3. Al-Rashood ST, Hassan GS, El-Messery SM, El-Taher KE, Hefnawy MM, Al-Omar MA, El-Subbagh HI. Synthesis, biological evaluation and molecular modeling study of some new thiazolodiazepine analogs as CNS active agents. Bioorg Med Chem Lett. 2016 Jan 15;26(2):445-53. doi: 10.1016/j.bmcl.2015.11.097. Epub 2015 Dec 7. PubMed PMID: 26706170.
4. Kadi A, Hefnawy M, Al-Majed A, Alonezi S, Asiri Y, Attia S, Abourashed E, El-Subbagh H. Liquid chromatographic high-throughput analysis of the new ultra-short acting hypnotic 'HIE-124' and its metabolite in mice serum using a monolithic silica column. Analyst. 2011 Feb 7;136(3):591-7. doi: 10.1039/c0an00381f. Epub 2010 Nov 16. PubMed PMID: 21079880.