ML 10375
Code | Size | Price |
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TAR-T28062-5mg | 5mg | £850.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T28062-50mg | 50mg | £1,661.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T28062-100mg | 100mg | £2,079.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Images
Documents
Further Information
Bioactivity:
ML 10375 is an antagonist of 5-HT4 receptor.
CAS:
174008-52-7
Formula:
C17H25ClN2O3
Molecular Weight:
340.85
Purity:
0.98
SMILES:
COc1cc(N)c(Cl)cc1C(=O)OCCN1CC(C)CC(C)C1
References
1. Derangeon M, Bozon V, Defamie N, Peineau N, Bourmeyster N, Sarrouilhe D, Argibay JA, Herv? JC. 5-HT4 and 5-HT2 receptors antagonistically influence gap junctional coupling between rat auricular myocytes. J Mol Cell Cardiol. 2010 Jan;48(1):220-9. doi: 10.1016/j.yjmcc.2009.07.005. PubMed PMID: 19615378.
2. Rivail L, Giner M, Gastineau M, Berthouze M, Soulier JL, Fischmeister R, Lezoualc'h F, Maigret B, Sicsic S, Berque-Bestel I. New insights into the human 5-HT4 receptor binding site: exploration of a hydrophobic pocket. Br J Pharmacol. 2004 Oct;143(3):361-70. PubMed PMID: 15351779; PubMed Central PMCID: PMC1575351.
3. Blondel O, Gastineau M, Langlois M, Fischmeister R. The 5-HT4 receptor antagonist ML10375 inhibits the constitutive activity of human 5-HT4(c) receptor. Br J Pharmacol. 1998 Oct;125(4):595-7. PubMed PMID: 9831890; PubMed Central PMCID: PMC1571008.