Holotoxin A1
| Code | Size | Price |
|---|
| TAR-T32096-5mg | 5mg | £850.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
Holotoxin A1 is a bioactive chemical.
CAS:
85344-35-0
Formula:
C66H104O31
Molecular Weight:
1393.527
Purity:
0.98
SMILES:
CO[C@@H]1[C@H](O)[C@H](CO)O[C@H](O[C@@H]2[C@H](O)CO[C@H](O[C@@H]3[C@H](C)O[C@H](O[C@@H]4OC[C@@H](O[C@@H]5O[C@H](CO)[C@@H](O)[C@@H](O[C@@H]6O[C@H](CO)[C@@H](O)[C@@H](OC)[C@@H]6O)[C@@H]5O)[C@H](O)[C@@H]4O[C@@H]4CC[C@@]5(C)[C@@H](CC[C@H]6C5=CC[C@@]57[C@H](C(=O)C[C@@]65C)[C@](C)(CCCC(C)=C)OC7=O)C4(C)C)[C@H](O)[C@@H]3O)[C@@H]2O)[C@@H]1O
References
1. Taylor M, Banerjee T, Ray S, Tatulian SA, Teter K. Protein-disulfide isomerase displaces the cholera toxin A1 subunit from the holotoxin without unfolding the A1 subunit. J Biol Chem. 2011 Jun 24;286(25):22090-100. doi: 10.1074/jbc.M111.237966. Epub 2011 May 4. PubMed PMID: 21543321; PubMed Central PMCID: PMC3121353.
2. Bradshaw M, Tepp WH, Whitemarsh RC, Pellett S, Johnson EA. Holotoxin Activity of Botulinum Neurotoxin Subtype A4 Originating from a Nontoxigenic Clostridium botulinum Expression System. Appl Environ Microbiol. 2014 Dec;80(23):7415-22. doi: 10.1128/AEM.01795-14. Epub 2014 Sep 19. PubMed PMID: 25239905; PubMed Central PMCID: PMC4249187.
3. Aminin DL, Lebedev AV, Levitski? DO. [The effect of holotoxin A1 on transport of calcium ions across the lipid models of biological membranes]. Biokhimiia. 1990 Feb;55(2):270-5. Russian. PubMed PMID: 2160291.
4. Sabo T, Kronman C, Mazor O. Ricin-Holotoxin-Based Vaccines: Induction of Potent Ricin-Neutralizing Antibodies. Methods Mol Biol. 2016;1403:683-94. doi: 10.1007/978-1-4939-3387-7_38. PubMed PMID: 27076160.