PWZ-029
| Code | Size | Price |
|---|
| TAR-T34197-5mg | 5mg | £850.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T34197-50mg | 50mg | £1,661.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T34197-100mg | 100mg | £2,079.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
PWZ-029 is an inverse agonist selective for α? GABAA receptors with nootropic effects.
CAS:
164025-33-6
Formula:
C14H14ClN3O2
Molecular Weight:
291.74
Purity:
0.98
SMILES:
COCc1ncn-2c1CN(C)C(=O)c1cc(Cl)ccc-21
References
Timi? Stameni? T, Joksimovi? S, Biawat P, Stankovi? T, Markovi? B, Cook JM, Savi? MM. Negative modulation of ?? GABAA receptors in rats may partially prevent memory impairment induced by MK-801, but not amphetamine- or MK-801-elicited hyperlocomotion. J Psychopharmacol. 2015 Sep;29(9):1013-24. doi: 10.1177/0269881115590601. Epub 2015 Jun 23. PubMed PMID: 26105958.
Mart?nez-Cu? C, Delatour B, Potier MC. Treating enhanced GABAergic inhibition in Down syndrome: use of GABA ?5-selective inverse agonists. Neurosci Biobehav Rev. 2014 Oct;46 Pt 2:218-27. doi: 10.1016/j.neubiorev.2013.12.008. Epub 2014 Jan 9. Review. PubMed PMID: 24412222.
Soto PL, Ator NA, Rallapalli SK, Biawat P, Clayton T, Cook JM, Weed MR. Allosteric modulation of GABA(A) receptor subtypes:effects on visual recognition and visuospatial working memory in rhesus monkeys [corrected]. Neuropsychopharmacology. 2013 Oct;38(11):2315-25. doi: 10.1038/npp.2013.137. Epub 2013 May 31. Erratum in: Neuropsychopharmacology. 2013 Nov;38(12):2553. PubMed PMID: 23722241; PubMed Central PMCID: PMC3773684.
Clayton T, Poe MM, Rallapalli S, Biawat P, Savi? MM, Rowlett JK, Gallos G, Emala CW, Kaczorowski CC, Stafford DC, Arnold LA, Cook JM. A Review of the Updated Pharmacophore for the Alpha 5 GABA(A) Benzodiazepine Receptor Model. Int J Med Chem. 2015;2015:430248. doi: 10.1155/2015/430248. Epub 2015 Nov 10. Review. PubMed PMID: 26682068; PubMed Central PMCID: PMC4657098.