IKD-8344
| Code | Size | Price |
|---|
| TAR-T35742-5mg | 5mg | £1,112.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
IKD-8344 is a macrocyclic dilactone originally isolated from an actinomycete species and has diverse biological activities, including anticancer, antimicrobial, and anthelmintic properties.1,2,3 It is cytotoxic to L5178Y murine leukemia cells (IC50 = 0.54 ng/ml).1 IKD-8344 inhibits growth of the mycelial form of C. albicans (MIC = 6.25 μg/ml) and potentiates the activity of polymyxin B against the multidrug-resistant pathogenic bacterium B. cenocepacia.2,3 It is active against T. spiralis in vitro and in vivo.1
CAS:
129046-69-1
Formula:
C48H76O12
Molecular Weight:
845.1
Purity:
0.98
SMILES:
O=C1O[C@]([C@@H](C)[C@]2([H])CC[C@@H](C)O2)([H])C[C@@]3([H])O[C@@](CC3)([H])[C@@H](C)C(C[C@@]4([H])O[C@](CC4)([H])[C@H](C)C(O[C@]([C@@H](C)[C@]5([H])CC[C@@H](C)O5)([H])C[C@@](CC6)([H])O[C@@]6([H])[C@@H](C)C(C[C@@](CC7)([H])O[C@]7([H])[C@@H]1C)=O)=O)=O
References
Loutet, S.A., El-Halfawy, O.M., Jassem, A.N., et al. Identification of synergists that potentiate the action of polymyxin B against Burkholderia cenocepacia. Int. J. Antimicrob. Agents 46(4), 376-380 (2015).
Minami, Y., Yoshida, K., Azuma, R., et al. Structure of a novel macrodiolide antibiotic IKD-8344. Tetrahedron Lett. 33(48), 7373-7376 (1992).
Hwang, E.I., Yun, B.S., Yeo, W.H., et al. Compound IKD-8344, a selective growth inhibitor against the mycelial form of Candida albicans, isolated from Streptomyces sp. A6792. J. Microbiol. Biotechnol. 15(4), 909-912 (2005).