Ruboxistaurin hydrochloride

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TargetMol
Product Code: TAR-T3689
Supplier: TargetMol
CodeSizePrice
TAR-T3689-1mg1mg£125.00
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TAR-T3689-5mg5mg£198.00
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TAR-T3689-1mL1 mL * 10 mM (in DMSO)£241.00
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TAR-T3689-10mg10mg£287.00
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TAR-T3689-25mg25mg£504.00
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TAR-T3689-50mg50mg£696.00
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TAR-T3689-100mg100mg£946.00
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TAR-T3689-500mg500mg£1,821.00
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Prices exclude any Taxes / VAT

Overview

Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃

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Documents

Further Information

Bioactivity:
Isozyme-selective inhibitor of protein kinase C (PKC); competitively and reversibly inhibits PKCβI and PKCβII (IC50 values are 4.7 and 5.9 nM respectively). Selective for PKCβ over other PKC isozymes (IC50values are 0.052, 0.25, 0.30, 0.36, 0.60 and >100 μM for PKC?, -δ, -γ, -α, -ε and -ζ respectively). Exhibits selectivity for PKC over other ATP-dependent kinases, including protein kinase A, casein kinase and src).
CAS:
169939-93-9
Formula:
C28H29ClN4O3
Molecular Weight:
505.02
Pathway:
Chromatin/Epigenetic; Cytoskeletal Signaling
Purity:
0.98
SMILES:
Cl.CN(C)C[C@@H]1CCn2cc(C3=C(C(=O)NC3=O)c3cn(CCO1)c1ccccc31)c1ccccc21
Target:
PKC

References

Wang SS, et al. Pharmazie. 2011, 66(11):881-7. Jirousek MR, et al. J Med Chem. 1996, 39(14):2664-71. Lei S, et al. Diabetes. 2013, 62(7):2318-28.